Yandy Diaz hit a two-run homer for the Rays, who have clinched the first AL wild-card berth.
It was a costly defeat for the Cubs, who have lost four in a row to see their National League wild-card hopes fade.
Zach McKinstry blasted a two-run homer, Spencer Torkelson hit a solo homer and Parker Meadows contributed a two-run triple.
Wilmer Flores had a solo homer and an RBI single for the Giants.
Closer Josh Hader allowed a solo homer in the ninth but regrouped to earn his 33rd save.
Persons:
J.P, Crawford, Steven Bisig, Ty France, Josh Rojas, Brock Burke, Trent Thornton, Nathan Eovaldi, Alejandro Kirk, Bo Bichette, Tampa Bay . Brandon Belt, Matt Chapman, Yusei Kikuchi, Yandy Diaz, Aaron Civale, Jose Abreu, Jose Urquidy, Alex Bregman, Gabriel Moreno, Zac Gallen, Carlos Santana, Blake Perkins, William Contreras, Caleb Boushley, Jose Cuas, Nick Pivetta, Garrett Whitlock, Whitlock, Trevor Story, Jordan Westburg's, Ryan Mountcastle's, Tyler Freeman, Bo Naylor, Brayan Rocchio, Cal Quantrill, Emmanuel Clase, Miguel Cabrera, Zach McKinstry, Spencer Torkelson, Parker Meadows, Ryan Jeffers, Max Kepler, Michael A, Taylor, Trevor Larnach, Kyle Farmer, Kody Funderburk, Alan Trejo, Brendan Rodgers, Elehuris Montero, Nolan Jones, Charlie Blackmon, Sean Bouchard, Josh Bell, Jake Burger, Jazz Chisholm, Huascar Brazoban, Tanner Scott, Endy Rodriguez, Colin Selby, Carter Kieboom, Dominic Smith, Lane Thomas, Keibert Ruiz, Jake Alu, Ozzie Albies, Forrest Wall, Martinez, Kai Correa, Gabe Kapler, Will Smith, Freddie Freeman, Lance Lynn, Wilmer Flores, Keaton Winn, Nick Martinez, Josh Hader, Trent Grisham, Xander Bogaerts, Yoan Moncada, Carlos Perez, Dylan, Nick Martini, Christian Encarnacion, Strand, Louis, Jonathan India, Tyler Stephenson socked, Spencer Steer, Noelvi Marte, Brandon Williamson, Carson Spiers, Carlos Rodon, Maikel Garcia, Salvador Perez, Perez, Kyle Isbel, Jordan Lyles, Aaron Judge, Austin Wells, Mickey Moniak, Davis Daniel, Connie Mack, Chase Silseth, Oakland's Ken Waldichuk
Organizations:
Seattle Mariners, Texas Rangers, Mobile, American League West, Mariners, Rangers, Houston Astros, Seattle, Blue Jays, Rays, Toronto, Tampa, American League, Astros, Diamondbacks, Arizona, Phoenix, Houston, AL West, National League, Miami, Brewers, Cubs, Milwaukee, Chicago, Red Sox, Orioles, Boston, Baltimore, American League East, Tigers, Cleveland, Detroit, Rockies, Minnesota, Colorado, The American League Central, Twins, Marlins, Pirates, Pittsburgh, League, Nationals, Braves, Washington, National League East, Minnesota Twins, Dodgers, Giants, San Francisco, Padres, White Sox, San Diego, Chicago . White Sox, Reds, Cardinals, Cincinnati, St, Miami Marlins, Royals, Yankees, Kansas City, New, Athletics, Los Angeles, Oakland, Philadelphia A's, of Fame, Angels, Thomson
Locations:
Seattle , Washington, USA, Texas, Tampa Bay . Brandon, Houston, Toronto, Detroit, Cleveland, Denver, Colorado, Miami, Atlanta, Angeles, San, San Diego, New York, pinstripes, Anaheim , Calif